// Articles and publications

Selected Publications

  1. Brogren CH and Lernmark A.: Islet Cell Antibodies in Diabetes. Clinics in Endocrinology and. Metabolism. 11 (2), 409-430. 1982.
  2. Brogren CH and Andersen P: BB Wistar Rat Monoclonal Autoantibodies. Metabolism – Clinical and Experimental, 32 (7), 165 (1983)
  3. Brogren CH, Baekkeskov S, Dyrberg T, Lernmark A, Marner B, Nerup J, and Papadopoulos GK.: Role of islet cell antibodies in the pathogenesis of type 1 diabetes. Current Problems in Clinical Biochemistry 12, 65-85. 1983..
  4. Brogren CH, Hirsch F, Wood P, Druet P, and Poussier P.: Production and characterization of a monoclonal islet cell surface autoantibody from the BB rat. Diabetologia 29 (5), 330-333. 1986.
  5. Brogren CH, Buschard K, Ropke C, and Rygaard J.: Genetics of the autoimmunne BB-rat in the study of diabetes mellitus heredity. In: Rygaard J et al. (eds). Immune-deficient Animals in Biomedical Research. Karger AG,Basel,NY, pp. 117-121, 1987.
  6. Buschard K, Brogren CH, Ropke C, and Rygaard J. Antigen expression of the pancreatic beta-cell is dependent on their functional state, as shown by a specific, BB rat monoclonal autoantibody IC2. APMIS. 96(4), 342-6. 1988.
  7. Scott FW, Cloutier HE, Souligny J, Riley WJ, Hoorfar J, and Brogren CH:  Diet and antibody production in the diabetes-prone BB-rat. In: Larkin P et al. (eds.).. Proceedings of the International IDF-Congress “immunology of Diabetes”, Sydney, Nov 1988, alias Diabetes 1988, Elsevier Science Publ. B.V., pp.763-767, 1989.
  8. Aaen K, Rygaard J, Josefsen K, Petersen H, Brogren CH, Horn T, and Buschard K.: Dependence of antigen expression on functional state of beta-cells. Diabetes. 39 (4), 697-701. 1990.
  9. Hoorfar J, Buschard K, and Brogren CH.: Impact of dietary protein and fat source on the development of insulin-dependent diabetes in the BB-rat. Diabetes Research 20 (1), 33-41. 1992.
  10. Moore A, Bonner-Weir S, and Weissleder R.: Noninvasive in vivo measurements of beta-cell mass in mouse model of diabetes. Diabetes 50, 2231-2236, 2001.
  11. Paty BW, Bonner-Weir S, Laughlin MR, McEwan AJ, Shapiro AMJ:
    Towards Developments of Imaging Modalities for Islets after: Insights from the National Institutes of Health Workshop om Beta-Cell Imaging. Transplantation 77 (8), 1133-1137, 2004.
  12. Saudek F, Brogren CH, Manohar S.  Imaging the Beta-cell mass: why and how. Rev Diabet Stud. 5(1), 6-12, 2008. Review
  13. Moore A.: Advances in beta-cell imaging. Eur J Radiol 70, 254-257, 2009.
  14. Malaisse WJ, Louchami K, and Sener A. Noninvasive imaging of pancreatic beta cells. Nat Rev Endocrinol. 5(7), 394-400. 2009. Review
  15. Kavishwar A, Medarova Z and Moore A.: Unique sphingomyelin patches are targets of a beta cell specific antibody. J Lipid Res, 2011 Jul 11 [Epub ahead of print]

Recent Meeting presentations:

  1. Brogren CH, Buschard K, Poussier P, and Rygaard P: Interspecies Cross-Reactivity of the Pancreatic-Islet Cell-Surface Specific Rat Monoclonal Autoantibody IC-2. Diabetologia 29 (8), A522, 1986,
  2. Brogren CH, Spitalnik SL, Shienvold FL, and Buschard K: Autoantigenic Determinant for the Monoclonal Autoantibody IC-2 Isolated from Diabetic BB-Rat. 7th Congress of Immunology, Berlin, Germany, July 30-August 5, 1989.
  3. Brogren CH, Gao WQ, Mia G, Buschard K, Bachmann MH, Contag CH, Renaut L, Carles MJ, Souyris N and Mondon P.: Development of the Pancreatic Beta-Cell Surface-Specific Monoclonal Autoantibody, IC2, for Assessing Beta-Cell Mass In Vivo. Diabetes 59, Suppl. 1, A59-A59, June 2010.
  4. Brogren CH, Engkilde K. Sørensen JØ, Wismann P, Gao W, Desai M, Mia GKA, Buschard K, Eliasson L, Bronsart LL, Bachmann MH, Contag CH, Renaut L, and Mondon P. The pancreatic beta-cell specific monoclonal autoantibody IC2 applied to noninvasive bioluminescent imaging in mice for estimating of residual beta-cell mass. What is its target? 3rd International Pancreatic Islet Symposium, Brussels, June 30-July 3, 2011
  5. Laura Bronsart, Michael H. Bachmann, Christian Stokes, Tobi L. Schmidt, Frank Cochran, Carl-Henrik Brogren, Laurence Renaut, Philippe Mondon, Christopher Contag: Genetic Engineering of the IC2 Autoantibody for Molecular Imaging of the Pancreatic Beta-Cell Mass, WMIC2011, San Diego, California, September 9., 2011.

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ImmunoSigns is a Biotech company founded in 1996. We offer you help in project management and R&D activities within biotechnology and immunodetection.

The core competance of ImmunoSigns is development and production of polyclonal and monoclonal antibodies and design and production of novel immunoassays and diagnostic kits, especially within the clinical area of diabetes and obesity.

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