Using 125-I iodinated  tracers with both native IC2 – the IgM format -, and the pepsin digested F(ab’)2 and Fab fragments, plus in comparison two other beta-cell reactive monoclonals the mouse IgM A2B5, the mouse IgG K14D10, and an isotype Rat IgM control, its has been confirmed in biodistribution studies in both mice and rats, that IC2 and its fragments bind the pancreatic beta-cells both in mice and rats. The in vivo studies are preliminary and need to be further explored using other radioisotopes and the soon available recombinant formats (presented at the American Diabetes Association Scientific Session in Orlando June 2010 – webcast on ADAs homepage).